Thursday, 30 July 2020 13:45

Anticoagulation news items. Week commencing 27th July 2020

Mortality risk associated with venous thromboembolism: a systematic review and Bayesian meta-analysis

The Lancet Haematology
In review of 86 RCTs, 52 of them, with data from >70 000 patients, were positive, with significantly increased VTE risk in patients in control vs. treatment groups (RR 2·74; 95% CrI 2·32–3·31,p<0·0001). Meta-analysis found causal effect of VTE prevention on mortality was null.


Management of anticoagulant-refractory thrombotic antiphospholipid syndrome

The Lancet Haematology
In this Viewpoint, authors discuss management, including general strategies to minimise thrombotic risk, intensification of anticoagulation, addition of antiplatelet agent, adjunctive treatment for thrombosis, immunomodulatory therapy, complement inhibition, and vascular options.


Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years

Pooled analyses of individual patient data from 7 RCTs of alteplase (n=6035) and registry studies support a positive benefit–risk profile of alteplase for acute ischaemic stroke, in patients aged >80 years, when administered according to other European regulatory criteria.




The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: