Mechanism suggested for development of rare blood clots with AstraZeneca covid 19 vaccine

Science Advances
This rare syndrome resembling heparin-induced thrombocytopenia (HIT), has been observed with ChAdOx1 (AZ) vaccine. Computational simulation study showed 3 adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to PF4, a protein implicated in pathogenesis of HIT.

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:

http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services