Sunday, 31 July 2022 13:19

Anticoagulation news items. Week commencing 25th July 2022

Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis

American Journal of Medicine
Review (6 observational studies, 1 RCT) found PPIs reduce upper GI bleeding (RR 0.67; 95% CI, 0.61-0.74) with benefit appearing to be most clearcut and substantial in patients with elevated risk of upper GI bleeding (e.g. NSAID or aspirin use, elevated bleeding risk score).


Edoxaban switching scheme: worth the risks?

Pharmaceutical Journal
At end of 2021, NHSE&I confirmed details of national scheme to switch thousands of patients to edoxaban. Article notes switching anticoagulants can be particularly complex and there is speculation patients will need to be switched again in future with advent of generic apixaban.



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: